The patient had no family history of PJS, indicating a possible de novo STK11 mutation, which is present in ∼45% of affected individuals with a negative family history of PJS.[10] It is also well-documented that ∼50% of the patients with PJS have to undergo surgery by age 18 because of polyps-related complications, including abdominal pain, rectal bleeding, anemia, bowel obstruction, or intussusception.[11] Intussusception caused by intraluminal polyps in PJS is a rare cause of intestinal obstruction. Here, STK11 is linked to anemia (phenotype).