Over-expression of ETS1 (E26 transformation specific-1), which belongs to the large family of transcription factors with ETS domain, was identified in a variety of solid tumors, including breast cancer, lung cancer, and specifically, renal carcinoma.[34] ETS1 was also considered as an oncogene that was involved in many BPs, such as invasion, proliferation, cell metabolism, and angiogenesis, and thus was linked to unfavorable survival. The gene discussed is ETS1; the disease is breast cancer.