Some study also showed that overexpression of SERPINE1 enhances tumor cell migration and invasion and plays a key role in metastasis development, conferring poor prognosis.[48] Up-regulation of phosphofructokinase-platelet (PFKP), one of the isoforms of phosphofructokinase-1 (PFK-1), had been frequently reported in different types of cancer. Here, SERPINE1 is linked to cancer.