We also evaluated the correlation between the expression of the 6 hypoxia-related genes and survival time via GEPIA online tools, which revealed that the expression levels of ANKZF1, ETS1, FBP1, PFKP, and PLAUR had a positive or negative correlation with the ccRCC patient's OS (Fig. 8A–E). This evidence concerns the gene ANKZF1 and nonpapillary renal cell carcinoma.