ETS1 and lung carcinoma: Over-expression of ETS1 (E26 transformation specific-1), which belongs to the large family of transcription factors with ETS domain, was identified in a variety of solid tumors, including breast cancer, lung cancer, and specifically, renal carcinoma.[34] ETS1 was also considered as an oncogene that was involved in many BPs, such as invasion, proliferation, cell metabolism, and angiogenesis, and thus was linked to unfavorable survival.