Through the study of Li et al,[16] overexpression of circ100395 can inhibit the proliferation, migration, and invasion of ovarian cancer cells by regulating the miR-1228/p53/EMT axis; at the same time, Cai et al[40] found that circ0000263 was significantly upregulated in cervical cancer cells and ultimately affected the expression of p53 gene. This evidence concerns the gene TP53 and cervical carcinoma.