LINC00261 is an epigenetically regulated tumor suppressor essential for the activation of the DNA damage response,[45] Several studies have proved that LINC00261 concerned to kinds of cancer cell proliferation, migration, and invasion.[46–48] A previous study discovered that HOXA10-AS was significantly upregulated in glioma tissues and cell lines; along these lines, increased HOXA10-AS expression levels were associated with higher grades of glioma. The gene discussed is LINC00261; the disease is central nervous system cancer.