In the ceRNA network, G6PC, HOXC8, VGLL2, HTR2C, MEOX2, HOXA7, and IGF2BP1 have the highest connection degree (connection degree ≥3) (see Table S7, Supplemental Digital Content, which illustrates the information of the ceRNA network), Therefore, we concluded that they might exert a strong influence on the progression of LGG to GBM. This evidence concerns the gene HTR2C and glioblastoma.