The knockdown of HOXA10-AS inhibited glioma cell proliferation and increased cell apoptosis rates.[49] HOXA10-AS was identified as a risk factor for oral squamous cell carcinoma and its expression was positively associated with tumor grade.[50] A previous study discovered that epithelial ovarian cancer HOXA11-AS has a tumor suppressor function in EOC which may be enhanced by the T allele.[51]. Here, HOXA11 is linked to central nervous system cancer.