Among these 13 hub lncRNAs, H19, HOTAIR, LINC00261, and HOXA10-AS had the highest connection degrees in the ceRNA network (connection degree ≥ 3) (Table S7, Supplemental Digital Content); therefore, we inferred that they might be the key lncRNAs in the malignant differentiation of glioma. This evidence concerns the gene LINC00261 and central nervous system cancer.