CCNB1 and hepatocellular carcinoma: CCNA2 was overexpressed in human HCC tissues.[54] Moreover, it was reported that CCNA2 was relative to a decrease in OS for HCC patients, based on the survival and expression data from TCGA.[55] Liu et al revealed that CCNB1 was highly expressed in HCC tissues compared with normal liver tissues.[56] In addition, the overexpression of CCNB1 was correlated to poor OS and DFS in HCC patients by bioinformatics analysis.[57] Our study also revealed that HCC patients with a high expression level of CCNA2 or CCNA2 exhibited worse OS and DFS compared to those with a low expression level.