EZH2 and neoplasm: EZH2 is a member of the polycomb group (PcG) protein family, which modifies transcription at the epigenetic level by regulating histone and DNA methylation.[67,68] Lots of studies have shown that many tumor suppressor genes are suppressed by EZH2 in malignancies and that EZH2 dysregulation plays a crucial role in carcinogenesis.[69,70] In our study, the expression of EZH2 was higher in HCC tumor tissue, and the high expression of EZH2 was associated with unfavorable OS and DFS in HCC patients.