EZH2 is a member of the polycomb group (PcG) protein family, which modifies transcription at the epigenetic level by regulating histone and DNA methylation.[67,68] Lots of studies have shown that many tumor suppressor genes are suppressed by EZH2 in malignancies and that EZH2 dysregulation plays a crucial role in carcinogenesis.[69,70] In our study, the expression of EZH2 was higher in HCC tumor tissue, and the high expression of EZH2 was associated with unfavorable OS and DFS in HCC patients. This evidence concerns the gene EZH2 and hepatocellular carcinoma.