AURKA is a mitotic serine/threonine kinase that regulates cell mitosis, cell division, and cell cycle progression.[41] AURKA overexpression has been observed in HCC.[42] And AURKA overexpression has been closely relative to the aggressive tumor characteristics,[43] poor prognosis,[44] and drug resistance[45] of HCC. This evidence concerns the gene MARK2 and hepatocellular carcinoma.