CDK2 and cancer: CDKN3 gene is involved in cell mitosis by modulating CDK1/CDK2 dephosphorylation, and its overexpression correlates with unfavorable survival in several cancers.[58] For HCC, CDKN3 not only promotes cell proliferation but also correlates with tumor pathological grade negatively.[59] CDK1, a member of the Ser/Thr protein kinase family, plays an essential role in the control of the eukaryotic cell cycle by modulating the centrosome cycle.