HIF1A and brain ischemia: There are a number of pathological conditions such as cerebral ischemia, acute kidney disease, ischemic heart disease, neonatal hypoxia-ischemic brain injury, cancer, and pulmonary arterial hypertension where both HIF1α and ROS have been reported to be important players (Chen et al., 2011; Chen et al., 2012; Weidemann et al., 2008; Tomsa et al., 2019; Semenza, 2014; Kibel et al., 2020; Sheldon et al., 2014; Qin et al., 2019; Semenza, 2012; Sosa et al., 2013; Bryant et al., 2016; Demarco et al., 2010).