Since HIF1α is a transcription factor, we next asked if peroxides play indispensable role in HIF-dependent transcription by examining Eno2 and Bnip3 mRNA expression levels, which are two established HIF1α target genes (Aminova et al., 2005; Poitz et al., 2014), in neuroblastoma SH-SY5Y cells. This evidence concerns the gene HIF1A and neuroblastoma.