CASP3 and cancer: Synchronously, DCT up-regulates the expression of gasdermin E (GSDME, the specific pyroptosis-inducing substrate cleaved by caspase-3) by inhibiting DNA methylation, which leads to the cleavage of caspase-3 and enhanced cancer cell pyroptosis (Boise and Collins, 2001; Shi et al., 2017; Kesavardhana et al., 2020).