Comparing their individual performances further revealed large differences in the individual RBP‐based classifiers' ability to discriminate ALS from control MN cultures, with ALS|TDP‐43 exhibiting the best performance and ALS|SFPQ the least (AUCALS|SFPQ = 0.7 < AUCALS|hnRNPK = 0.73 < AUCALS|FUS = 0.79 < AUCALS|hnRNPA1 = 0.85 < AUCALS|TDP43 = 0.9). Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.