A study on the relationship of singlenucleotide polymorphisms (Val125Leu, exon 3; Asn563Ser,exon 8; Arg670Gly, exon 12) in functionally important domainsof PECAM-1 in patients who were at risk of developingcoronary heart disease and myocardial infarction showed thatArg670Gly substitution can be a homozygous protector forthe development of myocardial infarction. Here, PECAM1 is linked to myocardial infarction.