Corticosteroids, leukotriene receptor antagonists, β2-agonists, anti-IgE, or anti-IL-5 are common therapies for asthma patients, while, even if inhaled corticosteroids are the recognized fundamental anti-inflammatory treatment for achieving asthma control, abuse usage of inhaled corticosteroids may increase the risk of pneumonia and cause invasive pneumococcal diseases [27, 28]. This evidence concerns the gene IGHE and susceptibility to pneumonia measurement.