RFS was also assessed, and the results showed that patients with PC with high transcriptional levels of UGT1A1 (P = 0.015), UGT1A4 (P = 0.025), and UGT1A10 (P = 0.0083) were significantly associated with shorter RFS (Figure 8). This evidence concerns the gene UGT1A1 and pachyonychia congenita.