Furthermore, M2 macrophages secreted CXCL13, activating a CXCL13/CXCR5/NFκB/p65/miR-934 positive feedback loop in CRC cells that induced immunosuppressive PMN formation and promoted CRC liver metastasis (Zhao et al., 2020). The gene discussed is CXCL13; the disease is colorectal carcinoma.