ORAI2 and acute myeloid leukemia: In addition, overexpression of Orai2 is responsible for enhanced SOCE in endothelial progenitor cells and pulmonary artery smooth muscle cells, whereas silencing Orai2 significantly attenuates thapsigargin-induced SOCE in the acute myeloid leukemia cell line HL60 (Diez-Bello et al., 1864; Fernandez et al., 2015; Dragoni et al., 2014; Chen et al., 2017).