Studies have found that the abnormal expression of LOX family proteins is usually associated with a variety of diseases related to ECM changes, such as fibrotic eosinophilic esophagitis (17), primary myelofibrosis (18), Wilson's disease (19), thoracic aortic aneurysm and dissection (20), fibrosis in systemic sclerosis (21), and human tumors. This evidence concerns the gene LOX and thoracic aortic aneurysm.