Kaneda et al.'s experiment may still have some imperfect aspects, such as only overexpression of LOX without silence; human GC cell line only uses MKN28 and KATO III; in vivo experiments only uses MKN28 cell line, etc. However, there is strong evidence that the mature form of LOX plays a key role in remodeling the extracellular matrix and promotes tumor development and metastasis (32, 33). The gene discussed is LOX; the disease is neoplasm.