In summary, antiproliferative activity of SLURP-1 in lung cancer cells is mainly mediated by interaction with α7-nAChR, which is realized by means of loop I. However, other molecular targets, e.g., EGFR and PDGFR, are involved in control of lung cancer cell migration by SLURP-1. Here, SLURP1 is linked to lung carcinoma.