STAT3 and cancer: For example, JQ1 and I-BET151 exert anti-cancer functions by reducing IKBKE expression to block the NF-κB signaling pathway, although tumor-associated macrophages in TNBC confound this effect by increasing IL-6 or IL-10/STAT3/IKBKE/NF-κB axis (Qiao et al., 2020).