For instance, in 58 breast samples, acetylated histone H4, H4K12ac, acetylated tubulin, HDAC1, HDAC2, and HDAC6 were lower in ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) than in normal mammary epithelium (Suzuki et al., 2009). This evidence concerns the gene HDAC2 and ductal breast carcinoma in situ.