Upregulated promoter region H3S10p activates oncogenes, such as RUNX1, DNMT1, SNAIL, and HER2, which promote BC progression (Mishra et al., 2001; Hsu et al., 2013; Gupta et al., 2014; Del Barco et al., 2018). The gene discussed is ERBB2; the disease is breast cancer.