In addition, independent of the canonical role of PRC2 or the catalytic function of EZH2, EZH2 also activate oncogenes in BC, such as Cyclin D1, c-Myc, NOTCH1, IL-6, IL-8, IL-11, TNF, CXCR4, CXCL18, MMP2, and MMP7 (Shi et al., 2007; Lee et al., 2011; Hartman et al., 2013; Gonzalez et al., 2014; Mahara et al., 2016; Li et al., 2017; Huang et al., 2018; Jiang et al., 2019). The gene discussed is CCND1; the disease is breast cancer.