A recent study demonstrated that p38 MAPK promotes the migration and metastatic activity of BRAF-mutated melanoma cells by inducing the degradation of PMCA4b, one of the key regulators involved in the maintenance of intracellular Ca2+ concentrations and linked to the modulation of cytoskeletal rearrangement (Naffa et al., 2020). The gene discussed is ATP2B4; the disease is melanoma.