Indeed, lamin expression can be variable between and even within cancer subtypes, as we have recently demonstrate in osteosarcoma: our findings demonstrated that lamin expression in human osteosarcoma cells scales with tumor aggressiveness in an integrated mechanism involving MKL1 nuclear shuttling and actin polymerization, as well as pRb expression and YAP nuclear content (Urciuoli et al., 2020). The gene discussed is MRTFA; the disease is osteosarcoma.