TP53 and head and neck squamous cell carcinoma: For instance, the canonical tumor suppressor gene TP53 was more frequently mutated in C2 and C3 patients than in C1 patients (p = 2.74e−15, Chi-square test), whereas another frequently deleted gene in HNSCC LRP1B showed a lower mutation rate in C2 compared with C1 and C3 (p = 0.0059, Chi-square test) (Figure 4B).