The current treatment of HNSCC includes surgery, radiation therapy, targeted therapy [epidermal growth factor receptor (EGFR)-targeting monoclonal antibody cetuximab], and chemotherapy with cytotoxic agents (such as cisplatin, methotrexate, gemcitabine, and bleomycin) (Johnson et al., 2020). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.