Additionally, global Bmal1 knockout abolished the rhythmic expression of soluble Aβ peptide in hippocampal interstitial fluid and increases amyloid plaque deposition in a mouse model of β-amyloidosis (APPPS1-21), which might be mediated by the increased expression of apolipoprotein E (Apoe) (Kress et al., 2018). The gene discussed is APOE; the disease is amyloidosis.