Knockdown of Prnp resulted in loss of SATB1 expression and reduction of metastatic capacity in CRC with Fyn and specificity protein 1(SP1) being involved in this process, indicating that PrPC may promote tumor metastasis via upregulating the PrPC-Fyn-SP1-SATB1 axis (18). Here, SP1 is linked to colorectal carcinoma.