Meanwhile, GSEA analysis was performed, revealing that C5AR2 was widely involved in metabolic pathways and biosynthesis in pan-cancer, including TNFα signaling via NFκB, IL6 JAK STAT3 signaling, IL2 STAT5 signaling, inflammatory response, KRAS signaling up, reactive oxygen species pathway, p53 pathway, and apoptosis. The gene discussed is IL6; the disease is cancer.