(43) illustrated that compound kushen injection activates macrophages form M2 to M1 via triggering TNFR1 and its downstream MAPK p38 signaling cascades, which induces HCC cells apoptosis and suppress HCC tumor growth and recurrence. Furtherly, we also design further mechanism research to verify whether AGTRAP could be involved in immune microenvironment of hepatocellular carcinoma by regulating MAPK signal pathway-induced macrophage polarization form M2 to M1. Here, TNFRSF1A is linked to hepatocellular carcinoma.