POF defined as amenorrhea for the preceding 6 months and FSH levels in the postmenopausal range at 2 yearsaPOF rate chemotherapy alone, 22%POF rate chemotherapy plus OFS, 8%POF OR: 0.30 (95% CI 0.09–0.97); P = 0.045-year cumulative incidence of pregnancy:chemotherapy alone, 12.2%chemotherapy plus OFS, 23.1%OR: 2.34 (95% CI 1.07–5.11); P = 0.03 The gene discussed is BRD2; the disease is amenorrhea.