MKI67 and gastrointestinal stromal tumor: High Ki67 expression is associated with poor pathological characteristics and aggressive behaviors of GISTs and can be used as an independent prognostic marker of GISTs (16), But in the existing GIST diagnostic and treatment systems, although it is unrealistic to directly use the Ki67 index to replace the NIH risk stratification of GISTs, the Ki67 index (cutoff value of 8%) can become a supplement to the NIH risk stratification standard for evaluating the prognosis of high-risk GISTs and selecting a suitable population for adjuvant imatinib therapy.