HRH2 and gastroesophageal reflux disease: Although several uncontrolled studies have shown improvement of chronic cough with antacid treatment, more recent randomized controlled trials have shown no differences between PPIs and placebo [16]. Although there is poor evidence that PPIs are universally beneficial for GERD-induced chronic cough, consensus guidelines recommend empiric therapy for at least eight weeks in conjunction with lifestyle changes such as dietary changes and weight loss [17]. The addition of a histamine H2 receptor antagonist and/or baclofen (Lioresal, 20 mg per day) may be helpful [18,19].