Clinical research has demonstrated improvement in progression-free survival with the combined use of the BRAF/MEK inhibitor in patients with metastatic melanoma and anaplastic thyroid cancer with the BRAF<sup>V600E </sup>mutation and has shown promise in redifferentiation of BRAF-positive RAIR differentiated thyroid cancer.  A 58-year-old woman went to her primary care physician for a growing mass on the left side of her neck. The gene discussed is BRAF; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.