In bleomycin-induced lung fibrosis model, one prototype CINOD compound, (S)-(5S)-5,6-bis(nitrooxy)hexyl)2-(6-methoxynaphthalen-2-yl) propanoate (NCX466), has shown a significant efficacy in reducing lung inflammation, the TGF-β signaling pathway, and the collagen accumulation, suggesting that COX inhibition along with NO donation may exhibit therapeutic potential in pulmonary fibrosis [75]. The gene discussed is TGFB1; the disease is pulmonary fibrosis.