Conditionally knocking out the autophagy-related protein 7 (Atg7) gene in the distal renal tubular epithelial cells from unilateral ureteral obstruction (UUO) mouse model can promote the activation of the TGF-β/Smad4 pathway and the NLRP3 inflammasome, as well as aggravate renal interstitial fibrosis [58]. The gene discussed is ATG7; the disease is Ureteral obstruction.