In an in vivo model of sepsis (NALB/c inbred male mice), luteolin was found to inhibit the phagocytosis of macrophages, downregulate the expression of myeloid differentiation factor (MyD)88 and toll-like receptor (TLR)4 in mouse peritoneal macrophages, regulate the expression of cytokines including TNF-α, IL-10, IL-1β, and IL-6, and reduced the level of peroxisome proliferator-activated receptor (PPAR)-γ and signal transducer and activator of transcription (STAT) protein. This evidence concerns the gene SOAT1 and Sepsis.