GSEA demonstrated that mucopolysaccharidoses, the butyrophilin BTN family, the EGFR/SMRTE pathway, IRF3- mediated induction of type I INF, FOXO-mediated transcription of cell cycle genes, and the ERK pathway were differentially enriched in association with high levels of CYBRD1 expression. The gene discussed is CYBRD1; the disease is mucopolysaccharidosis.