We then functionally analyzed mRNAs coexpressed with those 153 genome-instability-related lncRNAs, with the results indicating that these coexpressed mRNAs were enriched in leukocyte cell-cell adhesion and DNA-binding transcription activator activity, which are associated with genome instability [30, 31].We also found the enrichment of coexpressed mRNAs involved in cytokine−cytokine receptor interaction, Th1 and Th2 cell differentiation, PD−L1 expression, and PD−1 checkpoint pathway in cancer, which are also associated with cancer immunotherapy and genome instability [32–35]. The gene discussed is CD274; the disease is cancer.