GSEA revealed that the gene sets in the high-risk score group were enriched in “DNA repair” “glycolysis,” “apoptosis,” and pathways related to cancer, including p53 pathway, JAK-STAT3 signal pathway, and Notch signal pathway, providing strong evidence that these Hallmark pathways play a central part in in the resistance to radiotherapy in NSCLC. The gene discussed is STAT3; the disease is cancer.