We performed transcriptome analysis of the TCGA database of pan-cancer data and found that PIMREG expression was significantly negatively correlated with the immune component of TME in 11 cancers, including BRCA, ESCA, GBM, LUAD, LUSC, OV, PAAD, SKCM, STAD, TGCT, and UCEC, and negatively correlated with the stromal component of TME in 6 cancers, including BRCA, GBM, HNSC, LUAD, LUSAC, STAD, THYM, and UCEC. This evidence concerns the gene PIMREG and cancer.