Cox analysis indicated that the expression levels of PIMREG had closely correlations with OS in adrenocortical cancer (ACC) (p < 0.001), KICH (p < 0.001), KIRC (p < 0.001), KIRP (p < 0.001), LGG (p < 0.001), LIHC (p = 0.005), LUAD (p = 0.002), mesothelioma (MESO) (p < 0.001), PAAD (p < 0.001), pheochromocytoma and paraganglioma (PCPG) (p = 0.006), PRAD (p = 0.016), SARC (p = 0.020), THYM (p = 0.011), UCEC (p = 0.004), ocular melanomas (UVM) (p = 0.033) (Figure 3A). The gene discussed is PIMREG; the disease is hereditary pheochromocytoma-paraganglioma.