In addition, we also observed broad copy number loss of WRN, NAT1, NF2, and BUB1B, as well as copy number gain of MYC, ERBB2, EGFR, and CDK6 in high-CIN tumors (FDR < 0.01, Figure 3B). This evidence concerns the gene BUB1B and cervical squamous intraepithelial neoplasia.