These findings in part suggest and support previous reports that, (i) granule convergence/clustering precedes MTOC polarization towards the immune synapse in the context of NK-cancer immunosurveillance and (ii) cancer cells immunomodulate NK signalling by the perturbation of MTOC orientation signals (e.g. PLCγ → JNK1 pathways). The gene discussed is MAPK8; the disease is cancer.