Primary NK cells from sarcoma patients – increased degranulation and cytotoxicity against sarcoma cell linesPeripheral NK cells from melanoma patients – increased cytotoxicity against melanoma cell line and increased IFNγ productionMouse models of various cancers: colon, breast, fibrosarcomas – reduced tumour volume, increased CD107, TNF and IFNγ expression. The gene discussed is IFNG; the disease is sarcoma.