CD8A and leukemia: Recently, H60 transduction has been undertaken into B6-background leukemia or recipient mice and H60 peptide-H2Kb tetramers used to detect responding CD8+ T cells in combination with MHC-I deficient mice (H-2Kb-/-) to demonstrate how defects in leukemia antigen presentation promote exhaustion of donor T cells and ineffective GVL (42) (Table 1).