Sjögren’s syndrome (pSS) is commonly associated with the development of circulating autoantibodies, such as those targeting the ribonucleoproteins Ro/SSA and La/SSB (i.e., anti-Ro/SSa and anti-La/SSB autoantibodies), and rheumatoid factor (RF) (2). The gene discussed is CALR; the disease is peeling skin syndrome.