Several B7 superfamily costimulatory molecules, which also include CD80 (B7.1), CD86 (B7.2) or ICOSL, and PDL1 (21), are enhanced on the surface of SG EC in pSS patients, supporting their function as antigen-presenting cells, which results in priming of DC and T-cell activation (22–25). Here, CD86 is linked to peeling skin syndrome.