- Leukocytosis and neutrophilia (78)- ↓ B-lymphocytes and T-lymphocytes (78)- ↓ Neutrophil response to IL-8, TNF-α and IL-1β (79, 80)- ↑ Proinflammatory cytokines secretion (78, 81). This evidence concerns the gene TNF and Increased total leukocyte count.