We also performed an in silico analysis to evaluate the normalized mRNA expression of ACE2, TMPRSS2, CTSB (encoding cathepsin B), CTSL (encoding cathepsin L), and FURIN (encoding furin), both in normal adrenal glands (n=10) and in adrenocortical tumors (22 adenomas and 33 ACC) based on the high density oligonucleotide array data published by Giordano et al. (14) (deposited in the National Center for Biotechnology Information’s Gene Expression Omnibus, accession number GSE10927). The gene discussed is FURIN; the disease is adrenal cortex carcinoma.