To prevent Ent from delivering iron back to the potential pathogens (e.g., to Escherichia coli, one of the major pathogens of gut-origin sepsis), LCN2 chelates the Ent-iron complex and forms a structure which is not capable of transferring iron back to bacteria (Goetz et al., 2002; Johnson et al., 2010; Wu et al., 2010; Mori et al., 2016). The gene discussed is LCN2; the disease is Sepsis.