NFKB1 and idiopathic pulmonary arterial hypertension: Increased PWV resulting from large arterial stiffening has been associated with proinflammatory responses (increased TLR2, NF-kB activation) in pulmonary arterial ECs in vitro and in intralobar pulmonary arterial ECs from humans with idiopathic pulmonary arterial hypertension (Tan et al., 2014).