However, what kind of B cell subtype(s) becomes RANKL+ effector cell in the gingival tissue in response to the pathogen could not be ascertained with the current study, Finally, our findings indicate that the B cell cKO mouse model described here for RANKL can be adapted for defining the contribution of other B cell mediators in periodontitis progression. The gene discussed is TNFSF11; the disease is periodontitis.