A subset of B-regs (B regulatory cells), B10, has been found in gingival tissues of patients with and without periodontitis, and has been suggested to play anti-inflammatory and anti-bone resorbing functions due its ability to secrete IL-10 (Dai et al., 2017; Hu et al., 2017; Wang et al., 2017). The gene discussed is IL10; the disease is periodontitis.