In one study aiming to identify vulnerabilities in HSC-derived human MLL-rearranged AML cells resistant to chemotherapy, Zeisig et al. identified genes differentially expressed in MLL-rearranged HSC and common myeloid progenitor (CMP) cells and compared them with the Genomic Element Associated with drug Resistance (GEAR) database (Wang et al., 2017). Here, KMT2A is linked to acute myeloid leukemia.