Intriguingly, ABCC3 overexpression has been associated with chemoresistance and poor prognosis in both pediatric and adult AML (Steinbach et al., 2003; Benderra et al., 2005) and Zeisig et al. confirmed its higher expression in MLL-rearranged HSC cells and thus revealed the translational potential of targeting ABCC3 in MLL-rearranged leukemia (Zeisig et al., 2021). This evidence concerns the gene KMT2A and acute myeloid leukemia.