In addition, emerging evidence suggests that forcing the β-cells to secrete insulin constantly, termed insulin hypersecretion, might have the potential to accelerate the decline in β-cell function and thus may constitute a contributing factor to the progression of T2DM (Aston-Mourney et al., 2008; Rustenbeck et al., 2010). The gene discussed is INS; the disease is type 2 diabetes mellitus.