ZBP1-/RIPK3-deficient mice are hypersusceptible to lethal infection caused by IAV, failing to control IAV replication and succumbing to lethal respiratory infection (Nogusa et al., 2016; Thapa et al., 2016; Downey et al., 2017; Wang Y. et al., 2019). The gene discussed is RIPK3; the disease is infection.