A study found that TNF-α and IFN-γ synergism mediated RIPK1/FADD/CASP8 axis-derived PANoptosis in murine bone marrow-derived macrophages (BMDMs) drives pathology in COVID-19 and other diseases associated with cytokine storm (Karki et al., 2021). The gene discussed is CASP8; the disease is COVID-19.