An in vivo study reported significantly increased CX3CL1 expression in motor neurons in the anterior horn of the spinal cord in SOD1G93A mice, which is a model of amyotrophic lateral sclerosis (ALS), at 40 days; however, it decreased at 90 and 120 days due to motor neurons loss in the anterior horn. The gene discussed is CX3CL1; the disease is amyotrophic lateral sclerosis.