NFKB1 and Parkinson disease: Apocynin and Taurine significantly improved learning and memory deficits in mice by reducing NOX activation and related oxidative stress, as well as inhibiting M1 microglial polarization; moreover, they alleviated neuroinflammation and nerve injury in the paraquat and maneb-induced PD model by inhibiting the STAT1 and NF-κB pathway (Che et al., 2018; Hou et al., 2019).