MTOR and psychiatric disorder: Given the known reciprocal relationship between synaptic proteins and protein synthesis in ASD (Santini and Klann, 2014), it is possible that decreased NMDAR function may suppress mTOR signaling and translation of related proteins known to underlie various neurodevelopmental and psychiatric disorders, including ASD (Hoeffer and Klann, 2010; Costa-Mattioli and Monteggia, 2013; Borrie et al., 2017; Switon et al., 2017; Winden et al., 2018).