Previous studies have also established ASD-risk gene sets, including SFARI genes (all) (Abrahams et al., 2013), SFARI (high confidence, belonging to category 1) (Abrahams et al., 2013),5 FMRP targets (Darnell et al., 2011; Werling et al., 2016), De Novo Missense (protein-disrupting or missense rare de novo variants) (Iossifov et al., 2014; Werling et al., 2016), De Novo Variants (protein-disrupting rare de novo variants) (Iossifov et al., 2014; Werling et al., 2016), and AutismKB (Autism KnowledgeBase) (Xu et al., 2012; Yang et al., 2018; Supplementary Table 8). This evidence concerns the gene FMR1 and autism.