In gingival biopsies obtained from periodontitis or gingivitis-affected patients, the expression of the marker Vα24 and the different isoforms of CD1 were analyzed, observing a predominance of CD1d over CD1a, CD1b, and CD1c isoforms and higher number of CD1d+ cells and Vα24+ NKT cells in periodontitis patients, as compared with gingivitis patients [83]. Here, CD1B is linked to gingivitis.