POLE and carcinoma: The elevated mutation loads in adenoma and carcinoma crypts from POLE/POLD1 germline mutation carriers compared to normal intestinal crypts from each individual were also predominantly due to increased burdens of SBS10a and 10b (in POLE-mutant cases) and SBS10c and SBS10d (in POLD1-mutant cases) (Fig. 2f,g).