Other than the increase in incidence of colorectal, endometrial and other neoplasms, phenotype information from more than 100 POLE/POLD1 mutation carriers does not obviously reveal features of premature aging or early onset of age-related, non-neoplastic disease, and many survive into the late decades of the standard human lifespan16–18 (Supplementary Table 1). Here, POLD1 is linked to neoplasm.