On the other hand, the Hippo pathway can also regulate let-7b either directly through Dicer expression35, indirectly through Lin28 which is influenced by phosphorylated Merlin, an upstream tumour suppressor in the Hippo pathway34,36 or by p72 binding to the microprocessor complex needed in the biogenesis of miRNAs37. The gene discussed is DDX17; the disease is neoplasm.