The main findings of this study are: (a) The CSF and imaging biomarkers resulted in differential ATN profiles, mainly as a result of discordance in the biomarker modalities between the tau and neurodegeneration components; (b) PET tau positivity was a better predictor of short-term cognitive decline than PET Aβ or CSF pTau results. Here, MAPT is linked to oculocutaneous albinism type 1.